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4070 matches
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organism
protein
1)
Escherichia coli K12
fecR - Anti-sigma
transmembrane
signal transducer for ferric citrate transport; Regulation of iron dicitrate transport. In the absence of citrate FecR inactivates fecI. FecR is probably a
sensor
that recognizes iron dicitrate in the periplasm.
[a.k.a. b4292, AAC77248.1, NZ_STEB01000013.1,
Transmembrane sensor
]
2)
Homo sapiens
TMEM266 -
Transmembrane
protein 266; Voltage-
sensor
protein present on the post-synaptic side of glutamatergic mossy fibers and granule cells in the cerebellum. Despite the presence of a voltage-
sensor
segment, does not form a functional ion channel and its precise role remains unclear. Undergoes both rapid and slow structural rearrangements in response to changes in voltage. Contains a zinc-binding site that can regulate the slow conformational transition.
[a.k.a. 123591, HGNC:26763, Q2M3C6]
3)
Homo sapiens
MCTP1 - Multiple C2 and
transmembrane
domain-containing protein 1; Calcium
sensor
which is essential for the stabilization of normal baseline neurotransmitter release and for the induction and long-term maintenance of presynaptic homeostatic plasticity. Belongs to the MCTP family.
[a.k.a. ENST00000505078.5, URS00008C2DCA, XM_017009858]
4)
Homo sapiens
TM4SF5 -
Transmembrane
4 L6 family member 5; Acts as a lysosomal membrane arginine
sensor
. Forms a complex with MTOR and SLC38A9 on lysosomal membranes in an arginine-regulated manner, leading to arginine efflux which enables the activation of mTORC1 which subsequently leads to RPS6KB1 and EIF4EBP1 phosphorylations. Facilitates cell cycle G1/S phase progression and the translocation of the CDK4- CCND1 complex into the nucleus. CDKN1B and RHOA/ROCK signaling activity are involved in TM4SF5-mediated acceleration of G1/S phase progression ; Belongs to the L6 tetraspanin family.
[a.k.a. 9032, ENSP00000270560, AF027204]
5)
Homo sapiens
TRAM2 - Translocating chain-associated membrane protein 2; Necessary for collagen type I synthesis. May couple the activity of the ER Ca(2+) pump SERCA2B with the activity of the translocon. This coupling may increase the local Ca(2+) concentration at the site of collagen synthesis, and a high Ca(2+) concentration may be necessary for the function of molecular chaperones involved in collagen folding. Required for proper insertion of the first
transmembrane
helix N-terminus of TM4SF20 into the ER lumen, may act as a ceramide
sensor
for regulated alternative translocation (RAT).
[a.k.a. ENSP00000182527, OTTHUMG00000014850, AL049611]
6)
Homo sapiens
SLC26A5 - Prestin; Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ. Prestin is a bidirectional voltage-to-force converter, it can operate at microsecond rates. It uses cytoplasmic anions as extrinsic voltage
sensors
, probably chloride and bicarbonate. After binding to a site with millimolar affinity, these anions are translocated across the membrane in response to changes in the
transmembrane
voltage. They move towards the extracellular surface following hyperpolarization, and towards the cytoplasm [...]
[a.k.a. AAI00833.1, AAI00834.1, NP_996768]
7)
Homo sapiens
P4HTM -
Transmembrane
prolyl 4-hydroxylase; Catalyzes the post-translational formation of 4- hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen
sensor
and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex.
[a.k.a. HIFPH4, UPI0003B927C5, Q8WV55]
8)
Homo sapiens
TMEM100 -
Transmembrane
protein 100; Plays a role during embryonic arterial endothelium differentiation and vascular morphogenesis through the ACVRL1 receptor- dependent signaling pathway upon stimulation by bone morphogenetic proteins, such as GDF2/BMP9 and BMP10. Involved in the regulation of nociception, acting as a modulator of the interaction between TRPA1 and TRPV1, two molecular
sensors
and mediators of pain signals in dorsal root ganglia (DRG) neurons. Mechanistically, it weakens their interaction, thereby releasing the inhibition of TRPA1 by TRPV1 and increasing the single-channel open [...]
[a.k.a. NP_001093110.1, XM_017024815.1, ENST00000575685]
9)
Mus musculus
Tmem266 -
Transmembrane
protein 266; Voltage-
sensor
protein present on the post-synaptic side of glutamatergic mossy fibers and granule cells in the cerebellum. Despite the presence of a voltage-
sensor
segment, does not form a functional ion channel and its precise role remains unclear. Undergoes both rapid and slow structural rearrangements in response to changes in voltage. Contains a zinc-binding site that can regulate the slow conformational transition.
[a.k.a. UPI00000276E8, Transmembrane protein 266, UPI0000350B0C]
10)
Mus musculus
Mctp1 - Multiple C2 and
transmembrane
domain-containing protein 1; Calcium
sensor
which is essential for the stabilization of normal baseline neurotransmitter release and for the induction and long-term maintenance of presynaptic homeostatic plasticity.
[a.k.a. XP_017171131, AC124362, UPI00015AA075]
11)
Mus musculus
Tram2 - Translocating chain-associated membrane protein 2; Necessary for collagen type I synthesis. May couple the activity of the ER Ca(2+) pump SERCA2B with the activity of the translocon. This coupling may increase the local Ca(2+) concentration at the site of collagen synthesis, and a high Ca(2+) concentration may be necessary for the function of molecular chaperones involved in collagen folding. Required for proper insertion of the first
transmembrane
helix N-terminus of TM4SF20 into the ER lumen, may act as a ceramide
sensor
for regulated alternative translocation (RAT).
[a.k.a. ENSMUSG00000041779, ENSMUST00000037998.5, UPI0000024560]
12)
Mus musculus
Slc26a5 - Prestin; Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ. Prestin is a bidirectional voltage-to-force converter, it can operate at microsecond rates. It uses cytoplasmic anions as extrinsic voltage
sensors
, probably chloride and bicarbonate. After binding to a site with millimolar affinity, these anions are translocated across the membrane in response to changes in the
transmembrane
voltage. They move towards the extracellular surface following hyperpolarization, and towards the cytoplasm [...]
[a.k.a. XP_006535881.1, ENSMUSP00000030878, BC108987]
13)
Mus musculus
P4htm -
Transmembrane
prolyl 4-hydroxylase; Catalyzes the post-translational formation of 4- hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen
sensor
and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex.
[a.k.a. BC111871, XM_011242914.1, MGI:1921693]
14)
Mus musculus
Tmem100 -
Transmembrane
protein 100; Plays a role during embryonic arterial endothelium differentiation and vascular morphogenesis through the ACVRL1 receptor- dependent signaling pathway upon stimulation by bone morphogenetic proteins, such as GDF2/BMP9 and BMP10. Involved in the regulation of nociception, acting as a modulator of the interaction between TRPA1 and TRPV1, two molecular
sensors
and mediators of pain signals in dorsal root ganglia (DRG) neurons. Mechanistically, it weakens their interaction, thereby releasing the inhibition of TRPA1 by TRPV1 and increasing the single-channel open [...]
[a.k.a. XM_006534031.1, Q9CQG9, AK003574]
15)
Drosophila melanogaster
Mctp - Multiple C2 and
transmembrane
domain-containing protein; Calcium
sensor
which is essential for the stabilization of normal baseline neurotransmitter release and for the induction and long-term maintenance of presynaptic homeostatic plasticity.
[a.k.a. FBgn0034389, Mctp-PF, Mctp-PD]
16)
Caenorhabditis elegans
tmc-1 -
Transmembrane
channel-like protein 1; Sodium-
sensor
ion channel that acts specifically in salt taste chemosensation. Required for salt-evoked neuronal activity and behavioral avoidance of high concentrations of NaCl. Belongs to the TMC family.
[a.k.a. T13G4.3, NP_508221, WBGene00020490]
17)
Saccharomyces cerevisiae
SNF3 - Plasma membrane low glucose
sensor
, regulates glucose transport; high affinity
sensor
that contains 12 predicted
transmembrane
segments and a long C-terminal tail required for induction of hexose transporters; also senses fructose and mannose; SNF3 has a paralog, RGT2, that arose from the whole genome duplication.
[a.k.a. YDL194W, S000002353, D1234]
18)
Saccharomyces cerevisiae
RGT2 - Plasma membrane high glucose
sensor
that regulates glucose transport; low affinity sesnor that contains 12 predicted
transmembrane
segments and a long C-terminal tail required for hexose transporter induction; phosphorylation of the tail by Yck1p/Yck2p facilitates binding to the HXT co-repressors, Mth1p and Std1p; RGT2 has a paralog, SNF3, that arose from the whole genome duplication; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
[a.k.a. YDL138W, CAA98711.1, Q12300]
19)
Acetobacter aceti
AQS85828.1 - Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.
[a.k.a. A0U92_14790, aace:A0U92_14790, hypothetical protein,
Transmembrane sensor
]
20)
Acetobacter aceti
A0U92_14845 - Ferrichrysobactin receptor; Incomplete; partial on complete genome; missing start and stop; Derived by automated computational analysis using gene prediction method: Protein Homology.
[a.k.a.
Transmembrane sensor
, Hypothetical protein, Uncharacterized protein]
4070 matches
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